KEGG   Homo sapiens (human): 6573
Entry
6573              CDS       T01001                                 
Symbol
SLC19A1, CHMD, FOLT, IFC-1, IFC1, IMD114, MEGAF, REFC, RFC, RFC1, RFT-1, hRFC, hSLC19A1
Name
(RefSeq) solute carrier family 19 member 1
  KO
K14609  solute carrier family 19 (folate transporter), member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa01523  Antifolate resistance
hsa04977  Vitamin digestion and absorption
Disease
H01725  Primary immunodeficiency disease
H02699  Folate-responsive megaloblastic anemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04977 Vitamin digestion and absorption
    6573 (SLC19A1)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    6573 (SLC19A1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6573 (SLC19A1)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC19: Folate/thiamine transporter
   6573 (SLC19A1)
SSDB
Motif
Pfam: Folate_carrier MFS_1 DUF6767
Other DBs
NCBI-GeneID: 6573
NCBI-ProteinID: NP_919231
OMIM: 600424
HGNC: 10937
Ensembl: ENSG00000173638
UniProt: P41440
Structure
Position
21:complement(45502517..45563025)
AA seq 591 aa
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT
REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ
LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV
SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH
ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN
SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS
SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD
VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA
AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV
TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
NT seq 1776 nt   +upstreamnt  +downstreamnt
atggtgccctccagcccagcggtggagaagcaggtgcccgtggaacctgggcctgacccc
gagctccggtcctggcggcacctcgtgtgctacctttgcttctacggcttcatggcgcag
atacggccaggggagagcttcatcaccccctacctcctggggcccgacaagaacttcacg
cgggagcaggtcacgaacgagatcacgccggtgctgtcgtactcctacctggccgtgctg
gtgcccgtgttcctgctcaccgactacctgcgctacacgccggtgctgctgctgcagggg
ctcagcttcgtgtcggtgtggctgctgctgctgctgggccactcggtggcgcacatgcag
ctcatggagctcttctacagcgtcaccatggccgcgcgcatcgcctattcctcctacatc
ttctctctcgtgcggcccgcgcgctaccagcgtgtggccggctactcgcgcgctgcggtg
ctgctgggcgtgttcaccagctccgtgctgggccagctgctggtcactgtgggccgagtc
tccttctccacgctcaactacatctcgctggccttcctcaccttcagcgtggtcctcgcc
ctcttcctgaagcgccccaagcgcagcctcttcttcaaccgcgacgaccgggggcggtgc
gaaacctcggcttcggagctggagcgcatgaatcctggcccaggcgggaagctgggacac
gccctgcgggtggcctgtggggactcagtgctggcgcggatgctgcgggagctgggggac
agcctgcggcggccgcagctgcgcctgtggtccctctggtgggtcttcaactcggccggc
tactacctggtggtctactacgtgcacatcctgtggaacgaggtggaccccaccaccaac
agtgcgcgggtctacaacggcgcggcagatgctgcctccacgctgctgggcgccatcacg
tccttcgccgcgggcttcgtgaagatccgctgggcgcgctggtccaagctgctcatcgcg
ggcgtcacggccacgcaggcggggctggtcttccttctggcgcacacgcgccacccgagc
agcatctggctgtgctatgcggccttcgtgctgttccgcggctcctaccagttcctcgtg
cccatcgccacctttcagattgcatcttctctgtctaaagagctctgtgccctggtcttc
ggggtcaacacgttctttgccaccatcgtcaagaccatcatcactttcattgtctcggac
gtgcggggcctgggcctcccggtccgcaagcagttccagttatactccgtgtacttcctg
atcctgtccatcatctacttcttgggggccatgctggatggcctgcggcactgccagcgg
ggccaccacccgcggcagcccccggcccagggcctgaggagtgccgcggaggagaaggca
gcacaggcactgagcgtgcaggacaagggcctcggaggcctgcagccagcccagagcccg
ccgctttccccagaagacagcctgggggctgtggggccagcctccctggagcagagacag
agcgacccatacctggcccaggccccggccccgcaggcagctgaattcctgagcccagtg
acaaccccttccccctgcactctgtgctccgcccaagcctcaggccctgaggctgcagat
gagacttgtccccagctggctgtccatcctcctggtgtcagcaagctgggtttgcagtgt
cttccaagcgacggtgttcagaatgtgaaccagtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (65)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (63)   
DNA sequence (96)   
   RefSeq(nuc) (64)   
   GenBank (16)   
   EMBL (16)   
3D Structure (13)   
   PDB (13)   
Protein domain (3)   
   Pfam (3)   
All databases (209)   

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